After managing to squeeze 3.5 years of results and hard work in an awesome 7 minutes chalk talk, Magda got the DIGS-BB Wrap-up grant to finalize her exciting project and get it published in the coming year.
Here's what Magda has to say about her project:
"The genome of eukaryotic cells is protected by the nuclear envelope. The inside of nuclear envelope is lined with the lamina, a polymer meshwork which provides the nucleus with rigidity. The lamina is built from A- and B-type Lamins. Recently, both physical and biochemical properties of lamins have been a growing research focus as mutations in Lamin A/C were linked to a variety of diseases, collectively called laminopathies. It has been known that lamina is regulated via post-translational modifications of lamins. The best characterised is the mitotic phosphorylation of lamins which causes the disassembly of lamina. Recently, a growing number of mass spectrometry studies show that Lamin A/C is also a potential ubiquitination target. Nevertheless, the role of Lamin A/C ubiquitination and its contribution to molecular pathology of laminopathies remains unknown. In the course of my PhD project, I have experimentally verified Lamin A/C ubiquitination and characterised the mechanism of this modification. The DIGS-BB “Wrap up” funding will allow me to expand my research and focus on the cellular role of this process and the possible connection to laminopathies."