We are seeking highly motivated and creative colleagues to explore how reversible redox modifications control cell cycle decisions. We employ cell biological and biochemical techniques with an emphasis on single cell imaging and protein interactions. Several ambitious projects are available and can be tailored to individual interests and expertise.
Applicants should have a strong expertise in redox biology ideally involving cell biological techniques and/or protein biochemistry. Additional experience with programing languages such as Python, Matlab, Mathematica or R is beneficial. English language skills are essential; knowledge of German is not required. The position(s) can start immediately or upon mutual agreement. Salary will be according to the German TVL scale. In case of equivalent qualifications, disabled applicants will be preferentially considered. PhD applicants will have the possibility to additionally apply to the Dresden International PhD Programm (DIPP, http://www.dresd...
Congratulations to Alena for becoming the DIGS-BB Fellow! Here's what she has to say about her project and the award:
"The small molecule APC/C inhibitors I will develop during my PhD might be beneficial for cancer therapy in the future, especially in the light that indirect inhibition of the APC/C is already used for cancer treatment. Thanks to DIGS-BB Fellow Award I can move our ambitious project ahead and since it is my first own funding, it will also help fostering my future scientific career."
Big day for Gabor today as he submitted his PhD Thesis entitled "Target identification of ubiquitin- and ubiquitin-like-modified substrates of specific E2-E3 pairs by E2~dID". Looking forward to Gabor's defence next year!
Gabor and Igor spent an amazing couple of days in Croatia, getting charged by the sun, sea breeze and mixture of wonderful people. All this, while immersing themselves in the newest and hottest ubiquitin-related research. On top of that, both of them presented posters on their PhD projects making sure that the link between UFMylation and cell cycle as well as the advantages of E2~dID are getting proper attention.
Congratulations to Igor who just submitted his work "Targeted loss of function screen for cell cycle regulating E2 conjugating enzymes identifies UFC1 as a regulator of G1 phase progression". Already looking forward to Igor's defence at the end of the year!
Magda just defended her thesis on the "Insights into the molecular mechanism of lamin A/C ubiquitination" with flying colors and became the first student ever of the Mansfeld's to gain a PhD! She's got straight 1.0's in both the Rigorosum and the Viva presentation. Well Done!
Supported by her Wrap-Up PostDoc stipend she is now finishing the last experiments for her story on lamin ubiquitylation.
After managing to squeeze 3.5 years of results and hard work in an awesome 7 minutes chalk talk, Magda got the DIGS-BB Wrap-up grant to finalize her exciting project and get it published in the coming year.
Here's what Magda has to say about her project:
"The genome of eukaryotic cells is protected by the nuclear envelope. The inside of nuclear envelope is lined with the lamina, a polymer meshwork which provides the nucleus with rigidity. The lamina is built from A- and B-type Lamins. Recently, both physical and biochemical properties of lamins have been a growing research focus as mutations in Lamin A/C were linked to a variety of diseases, collectively called laminopathies. It has been known that lamina is regulated via post-translational modifications of lamins. The best characterised is the mitotic phosphorylation of lamins which causes the disassembly of lamina. Recently, a growing number of mass spectrometry studies show that Lamin A/C is also a potential ubiquitination target. Nev...