Also, in these difficult times of Corona virus crisis, when the social distancing became part of our daily life we still stick together! Every week, we organize an online meeting to talk and support each other as well as to disscuss scientific works.
Starting in August we have got three successful TAC meetings in a row.
First, Dilyana went throught 3,5 TAC meeting where she presented her almost finished Redox PhD project story. In September, Alena showed to the TAC comittee progress on her side and PhD projects after 2,75 years and also introduced further plans on finishing all the projects. As last this year, Kristyna presented her progress in November during 2nd TAC meeting. She got valuable feedback and help from the TAC members into the second half of her project.
All the presentations went well and got nice evaluations. Well done!
In the end of November Alena attended 21st EMBL PhD Symposium in Heidelberg with the theme ‘Facing the future’. Fitting to the theme Alena got the excellent opportunity to give a talk about her work and insights on a microfluidic delivery technique called 'Cell squeezing'. The audience was curious about this remarkable technique and gave Alena a valuable feedback. Further, Alena enjoyed awesome talks as well as a friendly and inspirative atmosphere. She can only recommend to attend the next symposium. :)
Once again we got together to wish a good luck to Doris who is leaving the lab, and welcome to Nadine who is joining the lab as a technician, and last but not least to celebrate several Birthdays which had happened since our last get together. We had a good time with a nicely designed dinner, several bottles of wine and chatty time spent together.
In the beginning of November the new "lab fairy" Nadine joined the group. After Doris left for another position, we tried to organize our stock, orders and reagents, which turned in a little mess. Luckily, Nadine came and things in the lab are running smoothly again.
In September this year Julia attended her first conference as a PhD student. Supported by a young investigator travel grant from the organisers she travelled to Saint Feliux de Guixols in Spain, where she joined the SPP1710 conference about thiol-based switches and redox regulation – from microbes to men’. On the conference Julia presented a poster showing the aim of her PhD project and how she plans to tackle it. Thanks to the supporting scientific community on the conference Julia collected many suggestions about her planed project, which will be helpful for her progress. :)
In the end of July, Alena and Jörg and Alena joined the lab retreat of Sonja Lorenz' laboratory. The lab retreat was in the beautiful Haus Neuglück near Bonn and the main part of the program was a workshop about Creative Problem Solving (CPS) given by Tim Dunne (Knowinnovation Ltd.). Joerg and Alena enjoyed the workshop very much and learnt how to use techniques of CPS in research as well as in everyday life. On top of it, they had lots of fun including an awesome BBQ and exciting time climbing in the trees :-). Thanks lot Sonja for your invitation!
Ann Wehman's lab from the Virchow Center of the University of Würzburg developed a wonderful degron-based approach to probe membrane topology by light microscopy in C. elegans. Kristyna from our lab showed that this approach can also be applied to human cells and to auxin-mediated degradation by monitoring the stability of mAID-tagged lamin A, a component of the nuclear lamina. In the movie below you can see that nuclear mAID-tagged lamin A is only degraded during mitosis after nuclear envelope breakdown in cells where TIR1- the ubiquitin ligase adapter responsible for mAID-dependent degradation is otherwise sequestered to the cytoplasm. Hence, only when the nuclear and cytoplasmic compartments mix in mitosis can mAID-lamin A be degraded and thus precisely marks the loss of nuclear envelope permeability. Have a look to see how this approach works in detail and how it can help studying your preferred organelle.
In the beginning of July Dilyana and Kristyna, both awarded by a Student Member Bursary from the Biochemical Society, went to Newcastle to present their projects at the conference on "Redox Signalling in Physiology, Ageing and Disease". Dilyana gave an exciting talk on how to detect endogenously produced ROS in living cells and how mitochondrial ROS might regulate cell cycle progression. Kristyna presented her story about NOX4-produced ROS and its impact on Cell cycle progression as a poster presentation. Both, talk and the poster, got big attention and valuable discussion. Moreover, Kristyna's poster got awarded by a Poster Prize from Biochemical Society. Well done, both of you :-)
Alena's first paper from a beautiful collaboration with Anna Liess from Sonja Lorenz' group in Würzburg just got published in Structure! Combining structural biology, biochemistry and cell biology our labs together reveal how ubiquitination of a conserved lysine residue close to the active site of the E2 ubiquitin-conjugating enzyme UBE2S regulates its activity and thereby the ability to generate K11-linked ubiquitin chains during mitosis.
Have a look here to read the full story and below to see a happy Alena - Well deserved!!